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Psychiatry (132) Digital Mental Health Interventions, e-Mental Health and Cyberpsychology (3293) Cost-Effectiveness and Economics (515) Depression and Mood Disorders; Suicide Prevention (2502) Registered Report (1557)

Published on in Vol 15 (2026)

Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/72866, first published .
Man in therapy session with therapist taking notes

Clinical Effectiveness and Cost-Effectiveness of Blended Treatment for Major Depression Compared With Treatment as Usual Within Routine Care in Europe: A Noninferiority Randomized Controlled Trial

Clinical Effectiveness and Cost-Effectiveness of Blended Treatment for Major Depression Compared With Treatment as Usual Within Routine Care in Europe: A Noninferiority Randomized Controlled Trial

Authors of this article:

Heleen Riper1, 2 Author Orcid Image ;   Annet Kleiboer1 Author Orcid Image ;   Adriaan Hoogendoorn2 Author Orcid Image ;   Judith Bosmans3 Author Orcid Image ;   Mieke Schulte1, 4 Author Orcid Image ;   Kim Mathiasen5 Author Orcid Image ;   Jean Baptiste Hazo6, 7 Author Orcid Image ;   Jerome Holtzmann8, 9 Author Orcid Image ;   Karine Chevreul6, 7 Author Orcid Image ;   David Daniel Ebert10 Author Orcid Image ;   Ingrid Titzler11, 12 Author Orcid Image ;   Mathias Berking11 Author Orcid Image ;   Burkhardt Funk13 Author Orcid Image ;   Anneke van Schaik2 Author Orcid Image ;   Lise Kemmeren14 Author Orcid Image ;   Roman Cieslak15, 16 Author Orcid Image ;   Ewelina Smoktunowicz17 Author Orcid Image ;   Anna Maj17 Author Orcid Image ;   Cristina Botella18, 19 Author Orcid Image ;   Azucena Garcia-Palacios18, 19 Author Orcid Image ;   Rosa Banos19, 20 Author Orcid Image ;   Rocío Herrero19, 20 Author Orcid Image ;   Gerhard Andersson21, 22, 23 Author Orcid Image ;   Naira Topooco21, 24 Author Orcid Image ;   Kristofer Vernmark21 Author Orcid Image ;   Thomas Berger25 Author Orcid Image ;   Tobias Krieger25 Author Orcid Image ;   Arlinda Cerga-Pashoja26, 27 Author Orcid Image ;   Asmae Doukani26 Author Orcid Image ;   Ricardo Araya28 Author Orcid Image ;   Eirini Karyotaki1, 29 Author Orcid Image ;   Spyros Kolovos3 Author Orcid Image ;   Mark Hoogendoorn30 Author Orcid Image ;   Ward van Breda30 Author Orcid Image ;   Pepijn van de Ven31 Author Orcid Image ;   Artur Rocha32 Author Orcid Image ;   Gonçalo Gonçalves32 Author Orcid Image ;   Pim Cuijpers1 Author Orcid Image
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