Chronic Conditions

Effectiveness and Safety of a Supplement Containing a Pharmacologically Active Basidiomycete Mushroom for Chronic Fatigue and Post–COVID-19 Fatigue Syndrome: Protocol for a Randomized Controlled Trial

Yunqing Xun, Tung Leong Fong, Guang Chen, Yibin Feng, Linda Chan, Ning Wang

JMIR Res Protoc 2026 (Jan 20); 15:e82633

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Prompting and Fine-Tuning Large Language Models for Parkinson Disease Diagnosis: Comparative Evaluation Study Using the PPMI Structured Dataset

Hyun-Ji Shin, Young Jin Jeong, Sungmin Jun, Do-Young Kang

JMIR Med Inform 2026 (Jan 15); 14:e77561

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Central Nervous System Mechanisms and Treatment Response in Chronic Ocular Surface Pain: Protocol for a Cross-Sectional Observational Phenotyping Study

Lindsey B De Lott, Steven E Harte, Chelsea Kaplan, David A Williams, Roni Shtein, Maria A Woodward, Alexander Tsodikov, Tatiana Deveney, Anat Galor, Anne Shea, Charles Schultz, Clare McKolay, Kathy A Scott, Daniel J Clauw

JMIR Res Protoc 2026 (Jan 15); 15:e84240

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Digital Health Interventions to Support Chronic Disease Management: Systematic Scoping Review

Abdullah Al Mahmud, Shane Joachim, Prem Prakash Jayaraman, Caitlin Learmonth, Shivani Tyagi, Abdur Rahim Mohammad Forkan, Muhammad Shuakat, Nilmini Wickramasinghe, Jack Wheeler, Stephanie Best, Alison Trainer

JMIR Mhealth Uhealth 2026 (Jan 14); 14:e63742

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Diet-Related Health Recommender Systems for Patients With Chronic Health Conditions: Scoping Review

Xiaolan Dong, Bei Yun, Anni Pakarinen, Zhuting Zheng, Hao Niu, Tian Jin, Changrong Yuan, Jingting Wang

J Med Internet Res 2026 (Jan 14); 28:e77726

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Normalization of Gastrointestinal Symptoms in Adults With Constipation With Daily Green Kiwifruit Consumption: Protocol for an Open-Label Intervention Study

Jasjot Maggo, Hwei Min Ng, Simone Birgit Bayer, Catherine L Wall, Caroline L Hoad, Luca Marciani, Jane Mullaney, Diana Cabrera, Karl Fraser, Janine M Cooney, Catrin S Günther, Tania Trower, Jeffery Tang, Olivier Gasser, Amber Milan, Warren C McNabb, Robin Spiller, Tamlin Conner, Chris Frampton, Meika Foster, Nicole C Roy, Richard B Gearry

JMIR Res Protoc 2026 (Jan 13); 15:e75286

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The Lived Experiences of Children Who Have Undergone Kidney Replacement Therapy and Their Families: Protocol for a Qualitative Systematic Review

Kenji Takao, Maki Fujitsuka, Shingo Ueki, Tomoyuki Sakai

JMIR Res Protoc 2026 (Jan 12); 15:e77725

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Ayurvedic Therapeutic Regimen as an Add-On to Optimized Conventional Management of Parkinson Disease: Protocol for an Exploratory Randomized Controlled Trial Evaluating Clinical, Cortical Excitability, Neuroimmune, and Autonomic Function Parameters

Umesh Chikkanna, Pramod Kumar Pal, Sophia Jameela, Rohan R Mahale, Nitish Kamble, Venkataram Shivakumar, Bharath Holla, Ravi Yadav, Vikram V Holla, Talakad Narasappa Sathyaprabha, Kaviraja Udupa, Srinibash Sahoo, Manjunath M Venkataswamy, Selva Ganapathy, Chandra Shekara Rao, Babita Yadav, Sreenithya M, Shivarama Varambally, Sulochana Bhat, Narayanam Srikanth, Kishore Kumar Ramakrishna

JMIR Res Protoc 2026 (Jan 09); 15:e83336

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Biopsychosocial Determinants, Diet Quality, Gastrointestinal Health, and Disease Activity in Adults With Rheumatoid Arthritis: Cross-Sectional Descriptive Study

Maureen McGarrity-Yoder, Emily K Cope, Heidi A Wayment, Alicia Rodriguez-Pla, Tracy E Crane

JMIR Res Protoc 2026 (Jan 08); 15:e79889

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Assessing the Quality of AI Responses to Patient Concerns About Axial Spondyloarthritis: Delphi-Based Evaluation

Jiaxin Bai, Xiaojian Ji, Jiali Yu, Yiwen Wang, Yufei Guo, Chao Xue, Wenrui Zhang, Jian Zhu

JMIR AI 2026 (Jan 07); 5:e79153

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Hashimoto Thyroiditis and Progression of Papillary Thyroid Cancer: 10-Year Retrospective Cohort Study

Xin Li, Xiangyun Yao, Rui Shan, Fang Mei, Shibing Song, Bangkai Sun, Chunhui Yuan, Zheng Liu

JMIR Cancer 2026 (Jan 06); 12:e80535

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Wearable Device Photoplethysmography As a Viable Tool to Longitudinally Monitor Vasoconstriction Biomarkers for Predicting Vaso-Occlusive Crisis in Sickle Cell Disease: Feasibility and Validation Study

Payal Shah, Sabrina Sy, Mingjing Chen, Michael CK Khoo, Thomas D Coates, Saranya Veluswamy

JMIR Hum Factors 2026 (Jan 06); 13:e75465

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Efficacy of an Ayurvedic Intervention as an Adjunct to Standard Care in Preventing Acute Pain Crises in Sickle Cell Anemia: Protocol for a Randomized Controlled Trial

U R Sekhar Namburi, Priya Thakare, Vaishali Kuchewar, Manish Deshmukh, Kalpana Kachare, Madhukar Tikas, Deepa Makhija, Bhogavalli Chandra Sekhara Rao, MN Suryawanshi, Satish Mahajan, Abha Sharma, N Srikanth, Ravinarayana Acharya

JMIR Res Protoc 2025 (Dec 31); 14:e76576

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Prognostic Prediction Models for Ulcerative Colitis: Systematic Review and Meta-Analysis

Zhijun Bu, Yuan Sun, Zeyang Shi, Liming Hu, Chuanlan Ju, Yuan Liu, Jing An, Huiyi Sun, Jianping Liu, Zhaolan Liu

J Med Internet Res 2025 (Dec 22); 27:e71944

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Community Advisors’ Effect on a Randomized Pragmatic Clinical Trial for Asthma Treatment: Retrospective Analysis

Wilson D Pace, Barbara Yawn, Nancy E Maher, Brianna Ericson, Elizabeth W Staton, Paulina Arias Hernandez, Bonnie Telon Sosa, Jean Kruse, Elliot Israel

J Particip Med 2025 (Dec 19); 17:e84679

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Mapping the Quality of German-Language Health Information on the Treatment of Knee Osteoarthritis: Cross-Sectional Analysis

Sandro Zacher, Jürgen Kasper, Julia Lauberger, Julia Lühnen, Lisa-Marie Redlich, Anke Steckelberg

JMIR Infodemiology 2025 (Dec 11); 5:e78007

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Real-World Efficacy and Safety of Zishenyizhi Pill for Cognitive Impairment Associated With Cerebral Small Vessel Disease: Protocol for a Multicenter Prospective Observational Study

Xiongxing Sun, Yao Xie, Rui Fang, Shanshan Zeng, Shigao Lin, Xukun Tang, Jie Tang, Tenghui Hu, Yuhui Zhang, Le Xie, Dahua Wu

JMIR Res Protoc 2025 (Dec 08); 14:e77661

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A Primary Care Program Based on Behavioral Reeducation and Abdominal Massage for Improving the Symptoms of Chronic Constipation: Protocol for a Randomized Controlled Trial

Cristina Segura-Bayona, Josep Vidal-Alaball, Anna Ramírez-Morros, Queralt Miró-Catalina, Anna Ruiz-Comellas

JMIR Res Protoc 2025 (Dec 04); 14:e72018

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A Mobile Game Intervention for Young Persons Living With HIV and Depression in Nigeria: Protocol for a Pilot Randomized Controlled Trial

Caleb Eliazer, Temitope Omotosho, Kehinde M Kuti, Leslie J Pierce, Dalton Gray, Carolyn M Audet, Olutosin Awolude, Oye Gureje, Bibilola Oladeji, Aima A Ahonkhai

JMIR Res Protoc 2025 (Dec 03); 14:e74199

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Patients’ Preferences Regarding Traditional Chinese Medicine for the Treatment of Chronic Obstructive Pulmonary Disease: Protocol for a Mixed Methods Study

Shaonan Liu, Tongtong Wu, Yan Yu, Yingkai Liu, Jing Wang, Xiaoli Chen, Xinfeng Guo

JMIR Res Protoc 2025 (Dec 02); 14:e75426

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