Chronic Conditions

Acupuncture Prescription Based on Thermal-Sensitized Acupoints for the Treatment of Knee Osteoarthritis: Protocol for a Randomized Controlled Pilot Trial

Xue-Zhou Wang, Tao-Tao Lv, Kua-Yue Zhang, Zhuo-Ya Chen, Li-Na Qin, Wei-Juan Gang, Wei-Heng Chen, Bao-Hong Mi

JMIR Res Protoc 2026 (Jan 28); 15:e81837

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Authors’ Reply: Bridging Neurofeedback and Structural Connectivity in Chronic Pain

Luke Spencer Bialostocki, Divya Bharatkumar Adhia, Damith Rathnayake Mudiyanselage, Mark Llewellyn Smith, Yusuf Ozgur Cakmak, Dirk De Ridder, Ramakrishnan Mani, Jerin Mathew

JMIR Res Protoc 2026 (Jan 28); 15:e89007

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Bridging Neurofeedback and Structural Connectivity in Chronic Pain

Alaeddin Acar, Diaa Yahya, Eray Tekirdaş

JMIR Res Protoc 2026 (Jan 28); 15:e87420

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The Role of Digital Media in Chronic Disease Self-Management: Protocol for a Multimethod Study of the DISELMA Research Consortium

Constanze Rossmann, Veronika Karnowski, Julia Metag, Juliana Raupp, Doreen Reifegerste, Claudia Riesmeyer, Nariman Sawalha, Alexandra Lux, Anna-Lena Esser, Rebecca Kammerer, Franca Singh, Natalie Rödel, Janine Brill, Elisabeth Gerling, Annemarie Wiedicke

JMIR Res Protoc 2026 (Jan 28); 15:e77811

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Effectiveness and Safety of Kangjia Decoction Granules for the Treatment of Hashimoto Thyroiditis: Protocol for a Randomized, Double-Blinded, Placebo-Controlled, Multicenter Clinical Trial

Duanchun Zhang, Dan Zhang, Xiaoxiao Qu, Huihong Cao, Yanming He

JMIR Res Protoc 2026 (Jan 26); 15:e80993

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Combining Noninvasive Brain Stimulation and Physiotherapy to Improve the Management of Chronic Low Back Pain in Veterans: Protocol for a Multi-Arm Randomized Controlled Trial

Frederique Dupuis, Yannick Tousignant-Laflamme, Pascale Marier Deschênes, Philippe Fournier, Ildephonse Nduwimana, Orlane Ballot, Loris Loisel, Anne Marie Pinard, Luc Lacombe, Pierre Langevin, Alain Gaumond, Jean-Sébastien Roy, Hugo Massé-Alarie

JMIR Res Protoc 2026 (Jan 26); 15:e78952

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Traditional Chinese Medicine Syndrome Differentiation of Adult Patients With Type 2 Diabetes and Metabolic Syndrome: Protocol for a Cross-Sectional Study

Jialing Zhang, Hoi Ki Wong, Zhilin Lin, Shuyan Zhong, Minxia Ma, Xuejiao Wang

JMIR Res Protoc 2026 (Jan 23); 15:e86217

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Effectiveness and Safety of a Supplement Containing a Pharmacologically Active Basidiomycete Mushroom for Chronic Fatigue and Post–COVID-19 Fatigue Syndrome: Protocol for a Randomized Controlled Trial

Yunqing Xun, Tung Leong Fong, Guang Chen, Yibin Feng, Linda Chan, Ning Wang

JMIR Res Protoc 2026 (Jan 20); 15:e82633

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Prompting and Fine-Tuning Large Language Models for Parkinson Disease Diagnosis: Comparative Evaluation Study Using the PPMI Structured Dataset

Hyun-Ji Shin, Young Jin Jeong, Sungmin Jun, Do-Young Kang

JMIR Med Inform 2026 (Jan 15); 14:e77561

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Central Nervous System Mechanisms and Treatment Response in Chronic Ocular Surface Pain: Protocol for a Cross-Sectional Observational Phenotyping Study

Lindsey B De Lott, Steven E Harte, Chelsea Kaplan, David A Williams, Roni Shtein, Maria A Woodward, Alexander Tsodikov, Tatiana Deveney, Anat Galor, Anne Shea, Charles Schultz, Clare McKolay, Kathy A Scott, Daniel J Clauw

JMIR Res Protoc 2026 (Jan 15); 15:e84240

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Digital Health Interventions to Support Chronic Disease Management: Systematic Scoping Review

Abdullah Al Mahmud, Shane Joachim, Prem Prakash Jayaraman, Caitlin Learmonth, Shivani Tyagi, Abdur Rahim Mohammad Forkan, Muhammad Shuakat, Nilmini Wickramasinghe, Jack Wheeler, Stephanie Best, Alison Trainer

JMIR Mhealth Uhealth 2026 (Jan 14); 14:e63742

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Diet-Related Health Recommender Systems for Patients With Chronic Health Conditions: Scoping Review

Xiaolan Dong, Bei Yun, Anni Pakarinen, Zhuting Zheng, Hao Niu, Tian Jin, Changrong Yuan, Jingting Wang

J Med Internet Res 2026 (Jan 14); 28:e77726

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Normalization of Gastrointestinal Symptoms in Adults With Constipation With Daily Green Kiwifruit Consumption: Protocol for an Open-Label Intervention Study

Jasjot Maggo, Hwei Min Ng, Simone Birgit Bayer, Catherine L Wall, Caroline L Hoad, Luca Marciani, Jane Mullaney, Diana Cabrera, Karl Fraser, Janine M Cooney, Catrin S Günther, Tania Trower, Jeffery Tang, Olivier Gasser, Amber Milan, Warren C McNabb, Robin Spiller, Tamlin Conner, Chris Frampton, Meika Foster, Nicole C Roy, Richard B Gearry

JMIR Res Protoc 2026 (Jan 13); 15:e75286

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The Lived Experiences of Children Who Have Undergone Kidney Replacement Therapy and Their Families: Protocol for a Qualitative Systematic Review

Kenji Takao, Maki Fujitsuka, Shingo Ueki, Tomoyuki Sakai

JMIR Res Protoc 2026 (Jan 12); 15:e77725

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Ayurvedic Therapeutic Regimen as an Add-On to Optimized Conventional Management of Parkinson Disease: Protocol for an Exploratory Randomized Controlled Trial Evaluating Clinical, Cortical Excitability, Neuroimmune, and Autonomic Function Parameters

Umesh Chikkanna, Pramod Kumar Pal, Sophia Jameela, Rohan R Mahale, Nitish Kamble, Venkataram Shivakumar, Bharath Holla, Ravi Yadav, Vikram V Holla, Talakad Narasappa Sathyaprabha, Kaviraja Udupa, Srinibash Sahoo, Manjunath M Venkataswamy, Selva Ganapathy, Chandra Shekara Rao, Babita Yadav, Sreenithya M, Shivarama Varambally, Sulochana Bhat, Narayanam Srikanth, Kishore Kumar Ramakrishna

JMIR Res Protoc 2026 (Jan 09); 15:e83336

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Biopsychosocial Determinants, Diet Quality, Gastrointestinal Health, and Disease Activity in Adults With Rheumatoid Arthritis: Cross-Sectional Descriptive Study

Maureen McGarrity-Yoder, Emily K Cope, Heidi A Wayment, Alicia Rodriguez-Pla, Tracy E Crane

JMIR Res Protoc 2026 (Jan 08); 15:e79889

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Assessing the Quality of AI Responses to Patient Concerns About Axial Spondyloarthritis: Delphi-Based Evaluation

Jiaxin Bai, Xiaojian Ji, Jiali Yu, Yiwen Wang, Yufei Guo, Chao Xue, Wenrui Zhang, Jian Zhu

JMIR AI 2026 (Jan 07); 5:e79153

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Hashimoto Thyroiditis and Progression of Papillary Thyroid Cancer: 10-Year Retrospective Cohort Study

Xin Li, Xiangyun Yao, Rui Shan, Fang Mei, Shibing Song, Bangkai Sun, Chunhui Yuan, Zheng Liu

JMIR Cancer 2026 (Jan 06); 12:e80535

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Wearable Device Photoplethysmography As a Viable Tool to Longitudinally Monitor Vasoconstriction Biomarkers for Predicting Vaso-Occlusive Crisis in Sickle Cell Disease: Feasibility and Validation Study

Payal Shah, Sabrina Sy, Mingjing Chen, Michael CK Khoo, Thomas D Coates, Saranya Veluswamy

JMIR Hum Factors 2026 (Jan 06); 13:e75465

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Efficacy of an Ayurvedic Intervention as an Adjunct to Standard Care in Preventing Acute Pain Crises in Sickle Cell Anemia: Protocol for a Randomized Controlled Trial

U R Sekhar Namburi, Priya Thakare, Vaishali Kuchewar, Manish Deshmukh, Kalpana Kachare, Madhukar Tikas, Deepa Makhija, Bhogavalli Chandra Sekhara Rao, MN Suryawanshi, Satish Mahajan, Abha Sharma, N Srikanth, Ravinarayana Acharya

JMIR Res Protoc 2025 (Dec 31); 14:e76576

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