<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="letter"><front><journal-meta><journal-id journal-id-type="nlm-ta">Interact J Med Res</journal-id><journal-id journal-id-type="publisher-id">i-jmr</journal-id><journal-id journal-id-type="index">3</journal-id><journal-title>Interactive Journal of Medical Research</journal-title><abbrev-journal-title>Interact J Med Res</abbrev-journal-title><issn pub-type="epub">1929-073X</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v14i1e70626</article-id><article-id pub-id-type="doi">10.2196/70626</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Letter</subject></subj-group></article-categories><title-group><article-title>Population Estimates of Self-Reported Depression and Anxiety in the US From a National Survey: Cross-Sectional Survey Study</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Pathak</surname><given-names>Yuvraj</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name name-style="western"><surname>Makk-Frid</surname><given-names>Elvira</given-names></name><degrees>MPP</degrees><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>West Health</institution><addr-line>10350 N Torrey Pines Rd</addr-line><addr-line>San Diego</addr-line><addr-line>CA</addr-line><country>United States</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Cardoso</surname><given-names>Taiane de Azevedo</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Brantner</surname><given-names>Carly</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Chen</surname><given-names>Runnan</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Yuvraj Pathak, PhD, West Health, 10350 N Torrey Pines Rd, San Diego, CA, 92037, United States, 1 858-535-7000; <email>pathakyuvraj@gmail.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>16</day><month>4</month><year>2025</year></pub-date><volume>14</volume><elocation-id>e70626</elocation-id><history><date date-type="received"><day>27</day><month>12</month><year>2024</year></date><date date-type="rev-recd"><day>05</day><month>03</month><year>2025</year></date><date date-type="accepted"><day>06</day><month>03</month><year>2025</year></date></history><copyright-statement>&#x00A9; Yuvraj Pathak, Elvira Makk-Frid. Originally published in the Interactive Journal of Medical Research (<ext-link ext-link-type="uri" xlink:href="https://www.i-jmr.org/">https://www.i-jmr.org/</ext-link>), 16.4.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Interactive Journal of Medical Research, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://www.i-jmr.org/">https://www.i-jmr.org/</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://www.i-jmr.org/2025/1/e70626"/><abstract><p>This letter shows that an estimated 31 million and 44 million adults self-report near-daily experiences of depression or anxiety, respectively. Of these, nearly a third have never spoken to a health care provider about it.</p></abstract><kwd-group><kwd>depression</kwd><kwd>anxiety</kwd><kwd>survey</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>Mental health conditions, including depression and anxiety, have been on the rise in the United States over the past several years [<xref ref-type="bibr" rid="ref1">1</xref>]. Data from the 2022 National Health Interview Survey indicate that the percentage of adults with anxiety and depression symptoms increased from 15.6% to 18.2% and 18.5% to 21.4%, respectively, between 2019 and 2022 [<xref ref-type="bibr" rid="ref2">2</xref>]. Depression and anxiety can manifest as fatigue, difficulty concentrating, problems sleeping, or changes in appetite and negatively affect daily life [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>].</p><p>Despite these impacts, people may not talk to their health care provider (HCP) due to stigma, cost, lack of access, or lack of insurance coverage [<xref ref-type="bibr" rid="ref5">5</xref>]. In particular, stereotypes and prejudice can prevent people from discussing their mental health experiences with friends, family, or even HCPs, which could prevent them from receiving needed care [<xref ref-type="bibr" rid="ref6">6</xref>].</p><p>In this paper, we estimate the number of people experiencing depression and anxiety almost daily based on a recent nationally representative survey. We also estimate how many of these people have never spoken to an HCP about their mental health. To the best of our knowledge, we are the first to report population-level estimates of self-reported experiences of depression and anxiety. While these results do not correspond to clinical diagnoses or a definite need for treatment, they provide timely information on an important issue and highlight the need to address mental and emotional health.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Ethical Considerations</title><p>The data for this cross-sectional study were obtained from a nationally representative West Health&#x2013;Gallup web and mail survey conducted from November 2023 to January 2024; 5149 adults aged &#x2265;18 years were sampled from the Gallup panel using stratified sampling spanning all 50 states and the District of Columbia. The survey response rate was 38%. Ethical approval was granted by Gallup&#x2019;s internal institutional review board. Participation was voluntary, and responses were deidentified. No personal health information or other sensitive information was disclosed to the authors. <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref> provides details.</p></sec><sec id="s2-2"><title>Statistics</title><p>Percentages were estimated as the count of responses divided by the number of respondents, multiplied by 100. Probability sampling weights provided by Gallup were used to calculate the population estimates.</p></sec><sec id="s2-3"><title>Outcomes</title><p>Survey questions focused on perceptions about health care. Our 2 main outcomes were self-reported experiences of depression and anxiety. The survey asked respondents how many days they experienced either condition in the past 30 days and if they had ever discussed depression or anxiety with their HCP. <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref> provides more details.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><p>We estimate that 31.1 million US adults experienced symptoms of depression on 20 or more days in the past month at the time of this survey. Of these people, an estimated 10.2 million never spoke to an HCP about their mental health (<xref ref-type="fig" rid="figure1">Figure 1</xref>).</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>An estimated 10.2 million adults experienced feelings of depression almost every day but had never spoken to a health care provider about it. The figure plots the percentage of people who reported ever talking to a health care provider about depression on the y-axis against the number of days (category) they self-reported experiences of depression. The estimated population size and sample size, broken down across number of days reported (categorical variable), are displayed below the x-axis. The population estimates at the top of the figure, to the right of the curly brackets, represent the population estimates of the number of people who reported experiences of depression by number of days (categorical variable) but never talked to their health care provider about it. Percentages may not add up to 100 as some respondents may not have responded to one or both questions. Full details are available in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="i-jmr_v14i1e70626_fig01.png"/></fig><p>Additionally, we estimated that 44.9 million adults experienced anxiety on 20 or more days in the past month. Of them, an estimated 15 million had never spoken to an HCP about it (<xref ref-type="fig" rid="figure2">Figure 2</xref>).</p><fig position="float" id="figure2"><label>Figure 2.</label><caption><p>An estimated 15.0 million adults experienced feelings of anxiety almost every day but had never spoken to a health care provider about it. The figure plots the percentage of people who reported ever talking to a health care provider about anxiety on the y-axis against the number of days (category) they self-reported experiences of anxiety. The estimated population size and sample size, broken down across number of days reported (categorical variable), are displayed below the x-axis. The population estimates at the top of the figure, to the right of the curly brackets, represent the population estimates of the number of people who reported experiences of anxiety by number of days (categorical variable) but never talked to their health care provider about it. Percentages may not add up to 100 as some respondents may not have responded to one or both questions. Full details are available in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="i-jmr_v14i1e70626_fig02.png"/></fig></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Principal Findings</title><p>We found that an estimated 53.8 million people have near-daily experiences of depression, anxiety, or both, and an estimated 18.6 million of them have never spoken to an HCP about these experiences.</p></sec><sec id="s4-2"><title>Limitations</title><p>Our findings are based on self-reported data, and we cannot assess if people (1) have a mental health diagnosis, (2) need professional care, or (3) have sought or received care. However, the findings provide useful population-level information about people&#x2019;s self-reported experiences with depression or anxiety even though the results are not prevalence estimates.</p></sec><sec id="s4-3"><title>Comparison to Prior Work</title><p>The Substance Abuse and Mental Health Services Administration reports that 58.7 million adults had any mental illness in 2023 [<xref ref-type="bibr" rid="ref7">7</xref>]. Based on the National Health Interview Survey, the US Centers for Disease Control and Prevention reports that 18.2% and 21.4% of adults experienced symptoms of anxiety and depression, respectively, in 2022. In comparison, we find that 53.8 million adults (18.5% of the adult population in 2024, as per author calculations) self-reported near-daily experiences of depression, anxiety, or both.</p></sec><sec id="s4-4"><title>Future Directions</title><p>This paper shows that millions of US adults experience depression, anxiety, or both on a near-daily basis but have never sought care from an HCP. The magnitude of these self-reported experiences, while alarming, does not correspond to a clinical diagnosis. Future research should aim to better understand the clinical needs of these people and build on the recent work showing a high degree of unmet need for mental health care [<xref ref-type="bibr" rid="ref8">8</xref>].</p></sec></sec></body><back><ack><p>EM-F had full access to all the data from the survey and takes responsibility for the integrity and accuracy of the data analysis. No artificial intelligence was used in the creation of this letter.</p></ack><notes><sec><title>Data Availability</title><p>The datasets generated or analyzed during this study are available from the corresponding author on reasonable request.</p></sec></notes><fn-group><fn fn-type="con"><p>Both YP and EM-F contributed equally to this letter and had full access to the survey and results.</p></fn><fn fn-type="conflict"><p>YP is an employee of Gary and Mary West Health Institute. EM-F is an employee of Gary and Mary West Health Policy Center. 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1</label><p>Sampling strategy, list of questions, and detailed tabulations.</p><media xlink:href="i-jmr_v14i1e70626_app1.docx" xlink:title="DOCX File, 112 KB"/></supplementary-material></app-group></back></article>